Here's an idea that was suggested to me today; People who resist change will still change. They just change slower than others.
The idea is that resisters are really trying to hold the status quo. If your early adopters and the middle packs move on to the new way of thinking and doing business the status quo eventually changes.
After a while your change resisters have adopted the new status quo.
Of course by this time, you are invested into the next (or the subsequent) change initiative.